DIRECT ENANTIOMERIC SEPARATION OF PHENGLUTARIMIDE BY CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：16

作者：

ABOULENEIN, HY ^{[1
]}

BAKR, SA ^{[1
]}

NICHOLLS, PJ ^{[1
]}

机构：

[1] UNIV WALES COLL CARDIFF,WELSH SCH PHARM,CARDIFF CF1 3XF,WALES

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 05期

关键词：

D O I：

10.1080/10826079408013388

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomeric separation of racemic phenglutarimide (PG) by chiral high performance liquid chromatography is reported using cellulose tris (3,5-dimethylphenyl carbamate) known as Chiralcel OD chiral stationary phase. Maximum resolution (R(S)) of 126 is obtained for the enantiomers of PG. The method could be applied for preparative scale chromatography and in the assay of PG in biological fluids.

引用

页码：1105 / 1110

页数：6

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