DIRECT CHROMATOGRAPHIC RESOLUTION OF RACEMIC CYCLOHEXYLAMINOGLUTETHIMIDE AND ITS ACETYLATED METABOLITE USING CELLULOSE-BASED CHIRAL STATIONARY PHASE

被引：7

作者：

ABOULENEIN, HY

BAKR, SA

机构：

[1] Drug Development Laboratory, Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211

来源：

CHIRALITY | 1991年 / 3卷 / 03期

关键词：

CHIRAL CHROMATOGRAPHY; CELLULOSE-BASED CHIRAL STATIONARY PHASE; AROMATASE INHIBITOR; CYCLOHEXYLAMINOGLUTETHIMIDE AND METABOLITE; ENANTIOMERIC SEPARATION;

D O I：

10.1002/chir.530030311

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Racemic cyclohexylaminoglutethimide (+/- ChAG) and its acetylated metabolite (+/- AChAG) were resolved by a direct chromatographic method using a Chiracel OD column without derivatization. Maximum resolutions (R) of 4.89 and 0.74 were obtained for the enantiomers of cyclohexylaminoglutethimide and its acetylated metabolite, respectively.

引用

页码：204 / 207

页数：4

共 8 条

[1] DIRECT CHROMATOGRAPHIC RESOLUTION OF RACEMIC AMINOGLUTETHIMIDE AND ITS ACETYLATED METABOLITE USING DIFFERENT CELLULOSE BASED CHIRAL STATIONARY PHASES [J].

ABOULENEIN, HY ;

ISLAM, MR .

CHROMATOGRAPHIA, 1990, 30 (3-4) :223-227

[2] DIRECT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF PENBUTOLOL ENANTIOMERS ON A CELLULOSE TRIS-3,5-DIMETHYLPHENYL CARBAMATE CHIRAL STATIONARY PHASE [J].

ABOULENEIN, HY ;

ISLAM, MR .

CHIRALITY, 1989, 1 (04) :301-304

[3]

ABOULENEIN HY, 1990, ANAL LETT, V23, P973

[4] DIRECT SEPARATION AND OPTIMIZATION OF TIMOLOL ENANTIOMERS ON A CELLULOSE TRIS-3,5-DIMETHYLPHENYLCARBAMATE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC CHIRAL STATIONARY PHASE [J].

ABOULENEIN, HY ;

ISLAM, MR .

JOURNAL OF CHROMATOGRAPHY, 1990, 511 :109-114

[5] DIRECT HPLC SEPARATION AND OPTIMIZATION OF CELIPROLOL ENANTIOMERS [J].

ABOULENEIN, HY ;

ISLAM, MR .

ANALYTICAL LETTERS, 1990, 23 (01) :83-91

[6]

HARTMANN RW, 1990, CHIRALITY AND BIOLOGICAL ACTIVITY, P185

[7]

HARTMANN RW, 1989, TRENDS MED CHEM 88, P821

[8] CHROMATOGRAPHIC RESOLUTION .11. CONTROLLED CHIRAL RECOGNITION OF CELLULOSE TRIPHENYLCARBAMATE DERIVATIVES SUPPORTED ON SILICA-GEL [J].

OKAMOTO, Y ;

KAWASHIMA, M ;

HATADA, K .

JOURNAL OF CHROMATOGRAPHY, 1986, 363 (02) :173-186

← 1 →