FLUOXETINE TREATMENT OF CHILDREN AND ADULTS WITH AUTISTIC DISORDER AND MENTAL-RETARDATION

被引：198

作者：

COOK, EH ^{[1
]}

ROWLETT, R ^{[1
]}

JASELSKIS, C ^{[1
]}

LEVENTHAL, BL ^{[1
]}

机构：

[1] UNIV CHICAGO,PEDIAT,CHICAGO,IL 60637

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 1992年 / 31卷 / 04期

关键词：

AUTISTIC DISORDER; MENTAL RETARDATION; FLUOXETINE; OBSESSIVE COMPULSIVE BEHAVIOR; PERSEVERATION;

D O I：

10.1097/00004583-199207000-00024

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

An open trial of pharmacological treatment with fluoxetine, ranging from 20 mg every other day to 80 mg per day, led to a significant improvement in Clinical Global Impressions ratings of Clinical Severity in 15 of 23 subjects with autistic disorder and 10 of 16 subjects with mental retardation. Six of 23 patients with autistic disorder and 3 of 16 patients with mental retardation had side effects which significantly interfered with function, consisting predominantly of restlessness, hyperactivity, agitation, decreased appetite, or insomnia. Double-blind studies of the efficacy of pharmacological agents that potently inhibit 5-HT uptake in the treatment of mental retardation coexisting with Axis I psychiatric disorders (especially obsessive-compulsive disorder) and autistic disorder are warranted.

引用

页码：739 / 745

页数：7

共 31 条

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