THE THERMODYNAMICS OF DNA STRUCTURES THAT CONTAIN LESIONS OR GUANINE TETRADS

被引：83

作者：

PILCH, DS

PLUM, GE

BRESLAUER, KJ

机构：

[1] Department of Chemistry, Rutgers - The State University of New Jersey, Piscataway, NJ 08855-0939

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-440X(95)80095-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is becoming increasingly apparent that energetic as well as structural information is required to develop a complete appreciation of the critical interrelationships between structure, energetics, and biological function. Motivated by this recognition, we have reviewed in this article the current state of the thermodynamic databases associated with lesion-containing DNA duplexes and DNA quadruplexes, while highlighting important considerations concerning the methods used to obtain the requisite data.

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页码：334 / 342

页数：9

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