DIBENZOQUINAZOLINE DIONES AS ANTIHYPERTENSIVE CYCLIC GUANOSINE-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS

被引:5
作者
BOOTH, RFG
BUCKHAM, SP
LUNT, DO
MANLEY, PW
PORTER, RA
机构
[1] SEARLE RES & DEV,DEPT BIOL,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND
[2] SEARLE RES & DEV,DEPT MED CHEM,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND
关键词
D O I
10.1016/0006-2952(87)90334-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:3517 / 3521
页数:5
相关论文
共 26 条
[11]  
KIMURA M, 1978, Journal of Pharmacobio-Dynamics, V1, P145
[12]  
KRAMER GL, 1980, HDB PHYSL 2, V2, P179
[13]   TREQUINSIN, A POTENT NEW ANTIHYPERTENSIVE VASODILATOR IN THE SERIES OF 2-(ARYLIMINO)-3-ALKYL-9,10-DIMETHOXY-3,4,6,7-TETRAHYDRO-2H-PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONES [J].
LAL, B ;
DOHADWALLA, AN ;
DADKAR, NK ;
DSA, A ;
DESOUZA, NJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (11) :1470-1480
[14]   THE SYNTHESIS OF PYRIMIDOAPORPHINES [J].
LENZ, GR .
TETRAHEDRON, 1984, 40 (20) :4003-4012
[15]   TISSUE AND SUBSTRATE-SPECIFICITY OF INHIBITION BY ALKOXY-ARYL-LACTAMS OF PLATELET AND ARTERIAL SMOOTH-MUSCLE CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES RELATIONSHIP TO PHARMACOLOGICAL ACTIVITY [J].
LUGNIER, C ;
STIERLE, A ;
BERETZ, A ;
SCHOEFFTER, P ;
LEBEC, A ;
WERMUTH, CG ;
CAZENAVE, JP ;
STOCLET, JC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 113 (03) :954-959
[16]  
MILLER JR, 1983, MOL PHARMACOL, V24, P235
[17]  
MURAD F, 1985, J CARDIOVASC PHARM, V7, pS111
[18]   2-(ALKYLTHIO)-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINES AS ADENOSINE CYCLIC 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS WITH POTENTIAL AS NEW CARDIOVASCULAR AGENTS [J].
NOVINSON, T ;
SPRINGER, RH ;
OBRIEN, DE ;
SCHOLTEN, MB ;
MILLER, JP ;
ROBINS, RK .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (04) :420-426
[19]   AGONIST-INDUCED ENDOTHELIUM-DEPENDENT RELAXATION IN RAT THORACIC AORTA MAY BE MEDIATED THROUGH CGMP [J].
RAPOPORT, RM ;
MURAD, F .
CIRCULATION RESEARCH, 1983, 52 (03) :352-357
[20]   HL-725, AN EXTREMELY POTENT INHIBITOR OF PLATELET PHOSPHODIESTERASE AND INDUCED PLATELET-AGGREGATION INVITRO [J].
RUPPERT, D ;
WEITHMANN, KU .
LIFE SCIENCES, 1982, 31 (19) :2037-2043