GUANYLYL CYCLASE-LINKED RECEPTORS

The guanylyl cyclase receptor family contains members that exist in both the particulate and soluble fractions of cell homogenates. Based on cloning studies, proteins with guanylyl cyclase activity contain a single transmembrane domain, or exist as heterodimers with no apparent transmembrane domains. The members containing the single transmembrane domain appear to act as cell surface receptors for peptides such as natriuretic peptides and bacterial heat-stable enterotoxins, while the heterodimeric forms are activated by nitric oxide. The concentrations of the intracellular messenger, cyclic GMP, then, are regulated by multiple primary signaling molecules, all of which appear to bind directly to the guanylyl cyclase enzyme.