RECOMBINANT PROTEINS FOR MEDICAL USE - THE ATTRACTIONS AND CHALLENGES

被引：19

作者：

KOTHS, K

机构：

[1] Chiron Technologies, Chiron Corporation, Emeryville, CA 94608

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/0958-1669(95)80112-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recombinant proteins that have survived the challenges of process development and clinical trials are becoming blockbuster medical products. Growth factors, enzymes, and antibodies are being improved by mutational approaches, fused with other proteins, and even chemically modified in vitro. Drug development and testing approaches have advanced, and proteins produced in transgenic animals are now becoming available. Future protein products might include cancer vaccines and therapies for a variety of genetic diseases, but alternative treatments involving gene therapy or small synthetic compounds will provide competition.

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页码：681 / 687

页数：7

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