BETA-CARBOLINE ALKALOIDS .7. 1,9-DIMETALLATED BETA-CARBOLINES - VERSATILE BUILDING-BLOCKS FOR THE TOTAL SYNTHESIS OF ALKALOIDS

被引：43

作者：

BRACHER, F ^{[1
]}

HILDEBRAND, D ^{[1
]}

机构：

[1] INST PHARMAZEUT CHEM,D-35037 MARBURG,GERMANY

来源：

TETRAHEDRON | 1994年 / 50卷 / 43期

关键词：

D O I：

10.1016/S0040-4020(01)89542-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of the dimetalated beta-carboline 6, prepared from 1-bromo-beta-carboline (4), with electrophiles are key steps in the syntheses of various beta-carboline alkaloids. Transmetalation of 6 with ZnCl2 followed by palladium-catalyzed cross coupling reaction with 2-chloxoquinoline gave the alkaloid nitramarine (14).

引用

页码：12329 / 12336

页数：8

共 17 条

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ROCCA, P ;

MARSAIS, F ;

GODARD, A ;

QUEGUINER, G .

TETRAHEDRON, 1993, 49 (16) :3325-3342

[14] THE CONSTITUTION OF YOHIMBINE AND RELATED ALKALOIDS .11. A SYNTHESIS OF SEMPERVIRINE [J].

SWAN, GA .

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[15]

TULYAGANOV TS, 1984, KHIM FARM ZH+, V18, P1474

[16]

WHALEY WM, 1951, ORG REACTIONS, V6, P151

[17]

WHALEY WM, 1951, ORG REACTIONS, V6, P74

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