New approach to diethyl 2-aminoalkylphosphonates

被引：14

作者：

Gajda, T

Nowalinska, M

Zawadzki, S

Zwierzak, A

机构：

[1] Institute of Organic Chemistry, Technical University (Politechnika), Zwirki 36

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1995年 / 105卷 / 1-4期

关键词：

diethyl; 2-aminoalkylphosphonates; 2-hydroxyalkylphosphonates; Mitsunobu reaction; Staudinger reaction; azidation of alcohols;

D O I：

10.1080/10426509508042044

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Diethyl 2-aminoalkylphosphonates 5 have been obtained in good yields in a one-step procedure employing the Mitsunobu reaction of diethyl 2-hydroxyalkylphosphonates 2 with hydrazoic acid, and subsequent treatment of the intermediate azides 3 with triphenylphosphine, followed by hydrolysis of the iminophosphoranes 4 with water.

引用

页码：45 / 50

页数：6

共 20 条

[1]

BLANCHARD J, 1976, TETRAHEDRON, V32, P455, DOI 10.1016/0040-4020(76)80062-2

[2]

BRIGOT G, 1979, TETRAHEDRON, V35, P1345

[3] PREPARATION OF OPTICALLY-ACTIVE 2-AMINOALKYLPHOSPHINIC AND PHOSPHONIC-ACIDS [J].