A MODEL FOR RNA EDITING IN KINETOPLASTID MITOCHONDRIA - GUIDE RNA MOLECULES TRANSCRIBED FROM MAXICIRCLE DNA PROVIDE THE EDITED INFORMATION

被引：489

作者：

BLUM, B ^{[1
]}

BAKALARA, N ^{[1
]}

SIMPSON, L ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

来源：

CELL | 1990年 / 60卷 / 02期

关键词：

D O I：

10.1016/0092-8674(90)90735-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A class of small RNA molecules possibly involved in RNA editing is present in the mitochondrion of Leishmania tarentolae. These "guide" RNA (gRNA) molecules are encoded in intergenic regions of the mitochondrial maxicircle DNA and contain sequences that represent precise complementary versions of the mature mRNAs within the edited regions. In addition, the 5′ portions of several gRNAs can form hybrids with mRNAs just 3′ of the preedited region. A model is presented in which a partial hybrid formed between the gRNA and preedited mRNA is substrate for multiple cycles of cleavage, addition or deletion of uridylates, and religation, eventually resulting in a complete hybrid between the gRNA and the mature edited mRNA. © 1990.

引用

页码：189 / 198

页数：10

共 30 条

[11] ORIGIN OF LIFE - THE RNA WORLD [J].

GILBERT, W .

NATURE, 1986, 319 (6055) :618-618

[12] SECONDARY STRUCTURE OF THE LARGE SUBUNIT RIBOSOMAL-RNA FROM ESCHERICHIA-COLI, ZEA-MAYS CHLOROPLAST, AND HUMAN AND MOUSE MITOCHONDRIAL RIBOSOMES [J].

GLOTZ, C ;

ZWIEB, C ;

BRIMACOMBE, R ;

EDWARDS, K ;

KOSSEL, H .

NUCLEIC ACIDS RESEARCH, 1981, 9 (14) :3287-3306

[13] INTERACTIONS BETWEEN SMALL NUCLEAR RIBONUCLEOPROTEIN-PARTICLES IN FORMATION OF SPLICEOSOMES [J].

KONARSKA, MM ;

SHARP, PA .

CELL, 1987, 49 (06) :763-774

[14]

Maniatis T., 1982, MOL CLONING

[15] RESTRICTION MAP, PARTIAL CLONING AND LOCALIZATION OF 9S AND 12S KINETOPLAST RNA GENES ON THE MAXICIRCLE COMPONENT OF THE KINETOPLAST DNA OF LEISHMANIA-TARENTOLAE [J].

MASUDA, H ;

SIMPSON, L ;

ROSENBLATT, H ;

SIMPSON, AM .

GENE, 1979, 6 (01) :51-73

[16] TRANSCRIPTION OF MOUSE RIBOSOMAL-RNA GENES BY RNA POLYMERASE-I - INVITRO AND INVIVO INITIATION AND PROCESSING SITES [J].

MILLER, KG ;

SOLLNERWEBB, B .

CELL, 1981, 27 (01) :165-174

[17] CHARACTERIZATION OF YEAST MITOCHONDRIAL RNASE-P - AN INTACT RNA SUBUNIT IS NOT ESSENTIAL FOR ACTIVITY INVITRO [J].

MORALES, MJ ;

WISE, CA ;

HOLLINGSWORTH, MJ ;

MARTIN, NC .

NUCLEIC ACIDS RESEARCH, 1989, 17 (17) :6865-6881

[18] YEAST RNASE-P - CATALYTIC ACTIVITY AND SUBSTRATE BINDING ARE SEPARATE FUNCTIONS [J].

NICHOLS, M ;

SOLL, D ;

WILLIS, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1379-1383

[19] STRUCTURE OF RIBOSOMAL-RNA [J].

NOLLER, HF .

ANNUAL REVIEW OF BIOCHEMISTRY, 1984, 53 :119-162

[20] PURIFICATION AND VISUALIZATION OF NATIVE SPLICEOSOMES [J].

REED, R ;

GRIFFITH, J ;

MANIATIS, T .

CELL, 1988, 53 (06) :949-961

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