THE PHARMACOLOGY OF VESAMICOL - AN INHIBITOR OF THE VESICULAR ACETYLCHOLINE TRANSPORTER

被引：49

作者：

PRIOR, C ^{[1
]}

MARSHALL, IG ^{[1
]}

PARSONS, SM ^{[1
]}

机构：

[1] UNIV CALIF SANTA BARBARA,DEPT CHEM,SANTA BARBARA,CA 93016

来源：

GENERAL PHARMACOLOGY | 1992年 / 23卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0306-3623(92)90280-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Vesamicol (2-[4-phenylpiperidino] cyclohexanol) inhibits the transport of acetylcholine into synaptic vesicles in cholinergic nerve terminals. 2. Recent pharmacological studies of the effects of vesamicol on skeletal neuromuscular transmission have revealed a pattern of activity for the compound consistent with the neurochemical observation of the mechanism of action of the compound. 3. Pharmacological manipulation of vesicular acetylcholine transport has been used to investigate the recycling and mobilization of synaptic vesicles within cholinergic nerve terminals. 4. In addition to its effects on vesicular acetylcholine transport, vesamicol also possesses some sodium channel and alpha-adrenoceptor blocking activity. 5. Vesamicol clearly represents a unique tool for investigating presynaptic mechanisms in cholinergic nerve terminals.

引用

页码：1017 / 1022

页数：6

共 40 条

[1] ANDERSON DC, 1983, MOL PHARMACOL, V24, P48
[2] ANDERSON DC, 1983, MOL PHARMACOL, V24, P55
[3] DEMONSTRATION OF A RECEPTOR IN TORPEDO SYNAPTIC VESICLES FOR THE ACETYLCHOLINE STORAGE BLOCKER L-TRANS-2-(4-PHENYL[3,4-H-3]-PIPERIDINO)CYCLOHEXANOL
BAHR, BA
PARSONS, SM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (07) : 2267 - 2270
[4] PRESYNAPTIC RECEPTORS IN THE NEUROMUSCULAR-JUNCTION
BOWMAN, WC
PRIOR, C
MARSHALL, IG
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 604 : 69 - 81
[5] BOWMAN WC, 1980, ANESTH ANALG, V59, P935
[6] Bowman WC, 1986, NEW NEUROMUS CULAR B, P141
[7] BOWMAN WC, 1972, INT ENCY PHARM THER, V14, P357
[8] ADENOSINE-TRIPHOSPHATASE ACTIVITY ASSOCIATED WITH PURIFIED CHOLINERGIC SYNAPTIC VESICLES OF TORPEDO-MARMORATA
BREER, H
MORRIS, SJ
WHITTAKER, VP
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 80 (01): : 313 - 318
[9] NEUROMUSCULAR BLOCKING ACTION OF 2-(4-PHENYLPIPERIDINO) CYCLOHEXANOL (AH 5183)
BRITTAIN, RT
LEVY, GP
TYERS, MB
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1969, 8 (01) : 93 - &
[10] IS AN ACETYLCHOLINE TRANSPORT-SYSTEM RESPONSIBLE FOR NONQUANTAL RELEASE OF ACETYLCHOLINE AT THE RODENT MYONEURAL JUNCTION
EDWARDS, C
DOLEZAL, V
TUCEK, S
ZEMKOVA, H
VYSKOCIL, F
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (10) : 3514 - 3518

← 1 2 3 4 →