IRREVERSIBLE ENZYME INHIBITORS .108. 6-(P-CHLOROACETYLANILINOMETHYL)-5-(P-CHLOROPHENYL)-2,4-DIAMINOPYRIMIDINE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE

被引：6

作者：

BAKER, BR

HUANG, PC

POGOLOTTI, AL

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1967年 / 10卷 / 06期

关键词：

D O I：

10.1021/jm00318a032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1134 / +

页数：1

共 21 条

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[13] ANALOGS OF TETRAHYDROFOLIC ACID .17. ON MODE OF BINDING OF P-AMINOBENZOYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO DIHYDROFOLIC REDUCTASE [J].

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[14] NON-CLASSICAL ANTIMETABOLITES .8. BRIDGE PRINCIPLE OF SPECIFICITY WITH EXO-ALKYLATING IRREVERSIBLE INHIBITORS [J].

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[15] ANALOGS OF TETRAHYDROFOLIC ACID .39(1,2). SELECTIVE BROMOACYLATION OF POLYFUNCTIONAL MOLECULES FOR SYNTHESIS OF ACTIVE-SITE-DIRECTED IRREVERSIBLE ENZYME INHIBITORS [J].

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