HYDROXYLATION AND GLUCOSIDE CONJUGATION IN THE MICROBIAL-METABOLISM OF THE DITERPENE SCLAREOL

被引：14

作者：

KOUZI, SA

MCCHESNEY, JD

机构：

[1] UNIV MISSISSIPPI,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

来源：

XENOBIOTICA | 1991年 / 21卷 / 10期

关键词：

D O I：

10.3109/00498259109043206

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The microbial metabolism of sclareol (1), a labdane diterpene ditertiary alcohol, was studied. Preliminary screening identified a number of microorganisms capable of metabolizing sclareol. 2. Preparative scale fermentation of growing cultures of Bacillus cereus UI-1477 resulted in the production of seven metabolites which have been characterized as 3-beta-hydroxysclareol (2), 2-alpha-hydroxysclareol (3), 18-hydroxysclareol (4), 2-alpha,18-dihydroxysclareol (6), 8-alpha,13-beta-dihydroxy-labd-14-en-3-beta-O-beta-D-glucoside (5), 8-alpha,13-beta-dihydroxy-labd-14-en-18-O-beta-D-glucoside (7), and 8-alpha,13-beta-dihydroxy-labd-14-en-2-alpha-O-beta-D-glucoside (10) by chemical, enzymic, and spectral data, especially 2D-n.m.r. techniques and thermospray liquid chromatography-mass spectrometry analysis.

引用

页码：1311 / 1323

页数：13

共 26 条

[11] THE USE OF MICROORGANISMS FOR THE STUDY OF DRUG-METABOLISM [J].