METALATION OF DIAZINES .5. SYNTHESIS OF ANALOGS OF BIOLOGICALLY-ACTIVE MOLECULES

被引：20

作者：

PLE, N

TURCK, A

BARDIN, F

QUEGUINER, G

机构：

[1] INSA-IRCOF, Laboratoire de Chimie Organique Fine et Hétérocyclique, URA 1429, Mt St Aignan, 76131

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 02期

关键词：

D O I：

10.1002/jhet.5570290229

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Chloro-4-methoxypyrimidine was lithiated by lithium 2,2,6,6-tetramethylpiperidide. The resulting lithio derivative was reacted with carbonyl derivatives and iodine. Synthesis of analogues of biologically active molecules is reported.

引用

页码：467 / 470

页数：4

共 14 条

[1] BISAGNI E, 1988, HETEROCYCLES, V27, P1674
[2] A VERSATILE ROUTE TO POTENTIAL DIHYDROFOLATE-REDUCTASE INHIBITORS VIA THE HITHERTO UNKNOWN 6-BENZYL-2-(O-METHYL)URACILS - SYNTHESIS OF ISOTRIMETHOPRIM
BOTTA, M
ARTICO, M
MASSA, S
GAMBACORTA, A
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (03) : 883 - 884
[3] LEDNICE D, 1984, ORGANIC CHEM DRUG SY, V1
[4] MATSON RJ, 1990, J ORG CHEM, V55, P3410
[5] SYNTHESIS OF SILYL AND STANNYL PYRIMIDINES
PARKANYI, C
CHO, NS
YOO, GS
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1988, 342 (01) : 1 - 7
[6] METALATION OF DIAZINES .3. NEW SYNTHESIS OF ANALOGS OF TRIMETHOPRIM AND OF BACIMETHRIN
PLE, N
TURCK, A
FIQUET, E
QUEGUINER, G
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (02) : 283 - 287
[7] RADINOV R, 1986, SYNTHESIS-STUTTGART, V11, P886
[8] RAUCKMAN BS, 1989, J MED CHEM, V32, P1827
[9] SELASSIE CD, 1989, J MED CHEM, V32, P1875
[10] METALATION OF DIAZINES .4. LITHIATION OF SYM-DISUBSTITUTED PYRAZINES
TURCK, A
TROHAY, D
MOJOVIC, L
PLE, N
QUEGUINER, G
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1991, 412 (03) : 301 - 310

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