Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder

被引：44

作者：

Dawson, E

Gill, M

Curtis, D

Castle, D

Hunt, N

Murray, R

Powell, J

机构：

[1] INST PSYCHIAT,DEPT NEUROSCI,LONDON SE5 8AF,ENGLAND

[2] INST PSYCHIAT,DEPT PSYCHOL MED,GENET SECT,LONDON SE5 8AF,ENGLAND

[3] ST JAMES HOSP,TRIN CTR HLTH SCI,DEPT PSYCHIAT,DUBLIN 8,IRELAND

[4] CHILTERN COMMUNITY MENTAL HLTH TEAM,OLD AMERSHAM HP7 0HG,BUCKS,ENGLAND

来源：

PSYCHIATRIC GENETICS | 1995年 / 5卷 / 04期

关键词：

association study; bipolar affective disorder; chromosome; 12; manic depression; PLAZA;

D O I：

10.1097/00041444-199524000-00005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosome 12q is a region of interest for the genetics of bipolar affective disorder because of reports of apparent cosegregation between this disorder and Darier's disease in a small number of families. Findings from a recent linkage study suggest that this chromosomal region may contain a susceptibility gene for bipolar affective disorder, We have found evidence of an allelic association between bipolar disorder and a marker at the pancreatic phospholipase A2 gene (PLAZA) in this region (p less than or equal to 0.01), These results are consistent with the linkage study, and warrant additional investigations.

引用

收藏

页码：177 / 180

页数：4

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