DNA Mismatch Repair in Eukaryotes and Bacteria

被引：101

作者：

Fukui, Kenji ^{[1
]}

机构：

[1] RIKEN SPring 8 Ctr, Harima Inst, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan

来源：

JOURNAL OF NUCLEIC ACIDS | 2010年 / 2010卷

关键词：

D O I：

10.4061/2010/260512

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. The basic features of the former system are expected to be universal among the vast majority of organisms including most bacteria. Here, I review the molecular mechanisms of eukaryotic and bacterial MMR, emphasizing on the similarities between them.

引用

页数：16

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