INHIBITION OF TUMOR-PROMOTER-ENHANCED PI-32-INCORPORATION INTO CELLULAR PHOSPHOLIPIDS BY FLAVONOLS FROM GENUS CHRYSOSPLENIUM

被引：5

作者：

ARISAWA, M ^{[1
]}

SHIMIZU, M ^{[1
]}

SATOMI, Y ^{[1
]}

NISHINO, A ^{[1
]}

NISHINO, H ^{[1
]}

IWASHIMA, A ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU,KYOTO 602,JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 03期

关键词：

CHRYSOSPLENIUM; FLAVONOL; ANTITUMOR PROMOTER;

D O I：

10.1002/ptr.2650090314

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Flavonol aglycones from the genus Chrysosplenium showed potential antitumour-promoter activity. Three flavonols, oxyayanin A and chrysosplenols D and E, markedly inhibited the incorporation of (32)Pi into phospholipids of confluent HeLa cells stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumour promoter. The potency of the flavonols proved to be similar to those of other antitumour-promoting flavonoids.

引用

页码：222 / 224

页数：3

共 19 条

[1]

ARISAWA M, 1993, CHEM PHARM BULL, V41, P571, DOI 10.1248/cpb.41.571

[2] ISOLATION AND IDENTIFICATION OF A CYTOTOXIC PRINCIPLE FROM CHRYSOSPLENIUM-GRAYANUM MAXIM (SAXIFRAGACEAE) AND ITS ANTITUMOR ACTIVITIES [J].

ARISAWA, M ;

BAI, H ;

SHIMIZU, S ;

KOSHIMURA, S ;

TANAKA, M ;

SASAKI, T ;

MORITA, N .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (12) :3274-3276

[3] ISOLATION AND CYTOTOXICITY OF 2 NEW FLAVONOIDS FROM CHRYSOSPLENIUM-GRAYANUM AND RELATED FLAVONOLS [J].

ARISAWA, M ;

HAYASHI, T ;

SHIMIZU, M ;

MORITA, N ;

BAI, H ;

KUZE, S ;

ITO, Y .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (03) :898-901

[4] INHIBITION OF TUMOR-PROMOTER-ENHANCED H-3 CHOLINE INCORPORATION INTO CELLULAR PHOSPHOLIPIDS BY PHLOROGLUCINOL DERIVATIVES FROM MALLOTUS-JAPONICUS [J].

ARISAWA, M ;

FUJITA, A ;

MORITA, N ;

OKUYAMA, T ;

NISHINO, H .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05) :1409-1412

[5] CHRYSOGRAYANON, A NOVEL CHROMONE DERIVATIVE FROM CHRYSOSPLENIUM-GRAYANUM MAXIM [J].

ARISAWA, M ;

SHIOJIMA, M ;

HUA, B ;

HAYASHI, T ;

TEZUKA, Y ;

TAGA, T ;

MIWA, Y ;

KIKUCHI, T ;

MORITA, N .

TETRAHEDRON LETTERS, 1992, 33 (40) :5977-5980

[6] INHIBITION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR PROMOTION AND ORNITHINE DECARBOXYLASE ACTIVITY BY QUERCETIN - POSSIBLE INVOLVEMENT OF LIPOXYGENASE INHIBITION [J].

KATO, R ;

NAKADATE, T ;

YAMAMOTO, S ;

SUGIMURA, T .

CARCINOGENESIS, 1983, 4 (10) :1301-1305

[7]

MORITA N, 1968, Yakugaku Zasshi, V88, P1277

[8]

NAKADATE T, 1984, GANN, V75, P214

[9] ROLE OF FLAVONOIDS IN SUPPRESSING THE ENHANCEMENT OF PHOSPHOLIPID-METABOLISM BY TUMOR PROMOTERS [J].

NISHINO, H ;

NAGAO, M ;

FUJIKI, H ;

SUGIMURA, T .

CANCER LETTERS, 1983, 21 (01) :1-8

[10] ENHANCED INCORPORATION OF RADIOACTIVE INORGANIC-PHOSPHATE INTO PHOSPHOLIPIDS OF HELA-CELLS BY TUMOR PROMOTERS [J].

NISHINO, H ;

FUJIKI, H ;

TERADA, M ;

SATO, S .

CARCINOGENESIS, 1983, 4 (01) :107-110

← 1 2 →