MICROCHANNEL PLATE FOR SURFACE-INDUCED DISSOCIATION IN MASS-SPECTROMETRY

A new method for surface-induced dissociation of molecular ions, applied to tandem mass spectrometry, Is achieved by collisions at a grazing angle on the inside channel surfaces of a microchannel plate. This technique, termed microchannel SID, is demonstrated by using both positive and negative parent ions In the energy range of 500–2000 eV. Fragmentation spectra of the pentapeptide leucine-enkephalin (555 dations) at 500 eV show good sequence information with a net fragmentation efficiency of 14 %. High mass fragmentation is demonstrated on (CsI)23Cs+ (6113 dattons), with the resultant spectrum showing all cluster fragments from n = 0 to 23. © 1990, American Chemical Society. All rights reserved.