CRYSTALLOGRAPHY, QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, AND MOLECULAR GRAPHICS IN A COMPARATIVE-ANALYSIS OF THE INHIBITION OF DIHYDROFOLATE-REDUCTASE FROM CHICKEN LIVER AND LACTOBACILLUS-CASEI BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(SUBSTITUTED-PHENYL)-S-TRIAZINESAN

被引：67

作者：

HANSCH, C

HATHAWAY, BA

GUO, ZR

SELASSIE, CD

DIETRICH, SW

BLANEY, JM

LANGRIDGE, R

VOLZ, KW

KAUFMAN, BT

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH PHARM,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN DIEGO,DEPT CHEM,LA JOLLA,CA 92093

[3] NIH,BETHESDA,MD 20205

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1984年 / 27卷 / 02期

关键词：

D O I：

10.1021/jm00368a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：129 / 143

页数：15

共 46 条

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[9] QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES
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