THE CONTROLLED PARENTERAL DELIVERY OF POLYPEPTIDES AND PROTEINS

被引：168

作者：

PITT, CG

机构：

[1] Amgen Inc., Thousand Oaks

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 59卷 / 03期

关键词：

Biodegradable polymer; Controlled delivery; Hydrogel; Microparticle; Parenteral delivery; Polypeptide; Porous membrane; Protein; Self-diffusion system;

D O I：

10.1016/0378-5173(90)90108-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Strategies for the controlled parenteral delivery of polypeptides and proteins are reviewed. The different approaches are divided into five classes: (a) hydrogels, (b) self-diffusion systems, (c) microparticles, (d) biodegradable polymers, and (e) porous membranes; self-regulated delivery represents an additional subset. These methods are discussed in the light of difficulties associated with delivery of proteins, including their low permeability, rapid proteolysis, and denaturation within the delivery system. © 1990.

引用

页码：173 / 196

页数：24

共 161 条

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