学术探索
学术期刊
新闻热点
数据分析
智能评审

EFFECTS OF SNAKE-VENOM PROTEINS ON BLOOD-PLATELETS

被引：101
作者：
KINI, RM
EVANS, HJ
机构：
[1] Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond
来源：
TOXICON | 1990年 / 28卷 / 12期
关键词：
D O I：
10.1016/0041-0101(90)90155-Z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
R. M. Kini and H. J. Evans. Review article-Effects of snake venom proteins on blood platelets. Toxicon 28, 1387-1422, 1990.-Snake venoms are complex mixtures which contain pharmacologically active polypeptides and proteins. Several snake venom constituents interfere in platelet aggregation, an important cellular process in thrombosis and hemostasis. These components range in size from small molecular weight polypeptides to high molecular weight proteins. Some of the proteins are enzymes, such as phospholipase A2, proteinases, nucleotidases, or l-amino acid oxidase, while others do not exhibit enzymatic activity. These components may initiate and/or inhibit platelet aggregation. Some venom factors induce platelet agglutination. This review deals with the physical characteristics of these venom factors, the mechanisms of their platelet effects, structure-function relationships, and their physiological significance. © 1990.
引用
收藏
页码：1387 / 1422
页数：36
相关论文
共 201 条
[1]   PURIFICATION OF BOTROCETIN FROM BOTHROPS-JARARACA VENOM - ANALYSIS OF THE BOTROCETIN-MEDIATED INTERACTION BETWEEN VONWILLEBRAND-FACTOR AND THE HUMAN-PLATELET MEMBRANE GLYCOPROTEIN-IB-IX COMPLEX [J].
ANDREWS, RK ;
BOOTH, WJ ;
GORMAN, JJ ;
CASTALDI, PA ;
BERNDT, MC .
BIOCHEMISTRY, 1989, 28 (21) :8317-8326
[2]  
ANDRIEUX A, 1989, J BIOL CHEM, V264, P9258
[3]  
ARRIAGADA E, 1989, ARCH BIOL MED EXP, V22, P97
[4]   TUMOR-CELL-INDUCED PLATELET-AGGREGATION IS A GLYCOPROTEIN-DEPENDENT AND LIPOXYGENASE-ASSOCIATED PROCESS [J].
BASTIDA, E ;
ALMIRALL, L ;
ORDINAS, A .
INTERNATIONAL JOURNAL OF CANCER, 1987, 39 (06) :760-763
[5]   CORRELATIONS BETWEEN ENZYMATIC-ACTIVITIES AND FACTORS ACTIVE ON BLOOD-COAGULATION AND PLATELET-AGGREGATION FROM VENOM OF VIPERA-ASPIS [J].
BOFFA, MC ;
BOFFA, GA .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 354 (02) :275-290
[6]   SIMPLE METHOD FOR PURIFICATION OF PHOSPHOLIPASE A FROM COBRA VENOM [J].
BRAGANCA, BM ;
SAMBRAY, YM ;
GHADIALLY, RC .
TOXICON, 1969, 7 (02) :151-+
[7]   ISOLATION OF POLYPEPTIDE INHIBITOR OF PHOSPHOLIPASE-A FROM COBRA VENOM [J].
BRAGANCA, BM ;
SAMBRAY, YM ;
SAMBRAY, RY .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1970, 13 (03) :410-&
[8]  
Brinkhous K.M., 1988, Hematology (New York), V7, P377
[9]  
Brinkhous K.M., 1988, Hematology (New York), V7, P363
[10]   VON WILLEBRAND SYNDROME INDUCED BY A BOTHROPS VENOM FACTOR - BIOASSAY FOR VENOM COAGGLUTININ [J].
BRINKHOUS, KM ;
BARNES, DS ;
POTTER, JY ;
READ, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :3230-3234
12345678910