EFFICIENT PATHWAYS TO (R)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND (S)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND SOME DERIVATIVES

被引：46

作者：

DANIELMEIER, K ^{[1
]}

STECKHAN, E ^{[1
]}

机构：

[1] UNIV BONN,INST ORGAN CHEM & BIOCHEM,D-53121 BONN,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 05期

关键词：

D O I：

10.1016/0957-4166(95)00144-E

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Oxazolidinones are a very interesting class of compounds due to their various pharmacological effects. Two new syntheses of enantiomerically pure (R)- and (S)-5-hydrolymethyl-2-oxazolidinone have been developed starting with D- mannitol, L-ascorbic acid and (R)- or (S)-malic acid. (R)- and (S)-5-hydroxylmethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives.

引用

页码：1181 / 1190

页数：10

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