ENANTIOSELECTIVE PALLADIUM-CATALYZED ALLYLIC ALKYLATION WITH C-2-SYMMETRICAL CHIRAL DIAMINE LIGANDS

被引：80

作者：

KUBOTA, H

NAKAJIMA, M

KOGA, K

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,TOKYO 113,JAPAN

[2] DAIICHI PHARMACEUT CO LTD,TOKYO R&D CTR,EDOGAWA KU,TOKYO 134,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)61472-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A C-2-symmetric chiral diamine ligand 1 was found to be effective for palladium catalyzed asymmetric allylic substitution of racemic 1,3-diphenyl-2-propenyl acetate 5 with dimethyl malonate. The X-ray analysis and NMR study of the palladium complex 7 with chiral diamine 1 have revealed the mechanism of high enantioselection.

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收藏

页码：8135 / 8138

页数：4

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