YEAST-EXPRESSED P55 PRECURSOR CORE PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DOES NOT ELICIT PROTECTIVE IMMUNITY IN CHIMPANZEES

被引：10

作者：

EMINI, EA ^{[1
]}

SCHLEIF, WA ^{[1
]}

QUINTERO, JC ^{[1
]}

CONARD, PG ^{[1
]}

EICHBERG, JW ^{[1
]}

VLASUK, GP ^{[1
]}

LEHMAN, ED ^{[1
]}

POLOKOFF, MA ^{[1
]}

SCHAEFFER, TF ^{[1
]}

SCHULTZ, LD ^{[1
]}

HOFMANN, KJ ^{[1
]}

LEWIS, JA ^{[1
]}

LARSON, VM ^{[1
]}

机构：

[1] SW FDN BIOMED RES,SAN ANTONIO,TX 78284

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 11期

关键词：

D O I：

10.1089/aid.1990.6.1247

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and pl7 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus. © 1990, Mary Ann Liebert, Inc. All rights reserved.

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页码：1247 / 1250

页数：4

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