THE INFLUENCE OF LOW FAT, LOW LACTOSE DIET ON DIARRHEA DURING PELVIC RADIOTHERAPY

被引:24
作者
BYE, A [1 ]
KAASA, S [1 ]
OSE, T [1 ]
SUNDFOR, K [1 ]
TROPE, C [1 ]
机构
[1] NORWEGIAN RADIUM HOSP,DEPT MED ONCOL & RADIOTHERAPY,N-0310 OSLO 3,NORWAY
关键词
D O I
10.1016/0261-5614(92)90075-2
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
In a prospective clinical trial 143 women undergoing pelvic radiotherapy for gynaecological malignancies, were randomized to receive either a low-fat, low-lactose diet (intervention group) or a regular diet (control group) in order to evaluate the possible impact of diet therapy on radiation induced diarrhoea, nausea and vomiting. The daily number and consistency of stools, use of antidiarrhoeal agents, nausea and vomiting were recorded before radiotherapy was begun (week 0), in the last week of therapy (week 6) and 6 weeks after the end of therapy (week 12). The intervention group used half the amount of antidiarrhoeal agents in week 6, than used by the control group (mean 0.6 tablets per day versus 1.1, p < 0.01). 14 patients (23%) in the intervention group reported diarrhoea, versus 32 (48%) in the control group (p < 0.01). In week 12 there were no differences in the use of antidiarrhoeal agents and the prevalence of diarrhoea between the groups.
引用
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页码:147 / 153
页数:7
相关论文
共 38 条
[11]  
Hofmann, The syndrome of ileal disease in the broken enterohepatic circulation: cholerheic enteropathy, Gastroenterology, 52, pp. 752-757, (1967)
[12]  
Mekhjian, Phillips, Hofmann, Colonic secretion of water and electrolytes induced by bile acids: Perfusion studies in man, Journal of Clinical Investigation, 50, pp. 1569-1577, (1971)
[13]  
Merrick, Bile acid malabsorption, Digestive Disease, 6, pp. 159-169, (1988)
[14]  
Stryker, Bartholomew, Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation, International Journal of Radiation Oncology, Biology, Physics, 12, pp. 789-792, (1986)
[15]  
Andersson, Isaksson, Sjogren, Fat-reduced diet in the symptomatic treatment of small bowel disease, Gut, 15, pp. 351-359, (1974)
[16]  
Hofmann, Poley, Cholestyramine treatment of diarrhea associated with ileal resection. New England, Journal of Medicine, 281, pp. 397-402, (1969)
[17]  
Chary, Thompson, A clinical trial evaluating cholestyramine to prevent diarrhea in patients maintained on low-fat diets during pelvic radiation therapy, International Journal of Radiation Oncology, Biology, Physics, 10, pp. 1885-1890, (1984)
[18]  
Heusinkveld, Manning, Aristizbal, Control of radiation-induced diarrhea with cholestyramine, International Journal of Radiation Oncology, Biology, Physics, 4, pp. 687-690, (1978)
[19]  
Stryker, Chung, Layser, Colestipol hydrochloride prophylaxis of diarrhea during pelvic radiotherapy, International Journal of Radiation Oncology, Biology, Physics, 9, pp. 185-190, (1983)
[20]  
Andersson, Effects of a fat-reduced diet on the faecal excretion of radioactivity following administration of 14C-Cholic acid and on the duodenal concentration of bile salt in patients with ileal disease, Nutrition and Metabolism, 20, pp. 254-263, (1976)