DIFFERENT TOXICITY OF N-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE (MPTP) ON THE NIGROSTRIATAL AND MESOLIMBIC PATHWAYS

被引：12

作者：

AMBROSIO, S ^{[1
]}

GERLI, P ^{[1
]}

PEREGO, C ^{[1
]}

ALGERI, S ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES, VIA ERITREA 62, I-20157 MILAN, ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1987年 / 133卷 / 02期

关键词：

D O I：

10.1016/0014-2999(87)90156-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of MPTP (30 mg/kg .times. 2) on dopamine content and tyrosine hydroxylase activity in striatal, limbic and cortical areas of C-57/B16 mice was studied. General dopamine depletion was observed 24 h after the treatment, but 30 days after administration recovery was complete in all but the striatum. At 24 h, tyrosine hydroxylase activity was decreased only in striatum. It is proposed that MPTP acts differently in striatum and in other dopaminergic areas.

引用

页码：239 / 241

页数：3

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