PARALLELS AND DECISIVE DIFFERENCES IN VITAMIN-B12 BIOSYNTHESES

被引：43

作者：

BLANCHE, F ^{[1
]}

THIBAUT, D ^{[1
]}

DEBUSSCHE, L ^{[1
]}

HERTLE, R ^{[1
]}

ZIPFEL, F ^{[1
]}

MULLER, G ^{[1
]}

机构：

[1] UNIV STUTTGART, INST ORGAN CHEM & ISOTOPENFORSCH, D-70174 STUTTGART, GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1993年 / 32卷 / 11期

关键词：

D O I：

10.1002/anie.199316511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single reactions that are, in principle, similar to those in the cobalt‐free biosynthesis of hydrogenbyrinic acid (1) in the aerobe P. denitrificans, but with cobalt‐coordinated substrates, occur in the biosynthesis of cobyrinic acid (2) in the anaerobe P. shermanii. This information was obtained from incorporation experiments with 3H/14C doubly labeled precursors from the biosynthetic pathway of P. denitrificans. Previously it had been established that in P. shermanii and the biosynthesis of 2, the cobalt ion is incorporated much earlier than in P. denitrificans. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1651 / 1653

页数：3

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