TC-99M AND DEUTERIUM-LABELED RADIODIAGNOSTICS - COMPARISON OF HMPAO WITH CYTECTRENE DERIVATIVES OF CYCLIC AMINES

被引：6

作者：

WENZEL, M

KLINGE, C

SAIDI, M

机构：

[1] Pharmazeutisches Institut, Freie Universität Berlin

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 11期

关键词：

TC-99M; DEUTERIUM; CYTECTREN; HMPAO; BRAIN UPTAKE;

D O I：

10.1002/jlcr.2580331107

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

HMPAO-d2 and Deuterium labelled esters of Cytectrenecarbonic ester with alcohols of cyclic amines were synthesized and additional labelled with Tc-99m. The organ distribution in rats showed a higher brain uptake of the cytectrene ester than HMPAO with a far higher Tc-99m concentration ratio brain/blood. The deuterated compounds showed a lower Tc-99m concentration in blood, but no higher uptake in brain.

引用

页码：1039 / 1051

页数：13

共 11 条

[1]

BALLINGER JR, 1990, J NUCL MED, V31, P118

[2]

CANNING LR, 1986, Patent No. 194843

[3]

HUNG JC, 1989, NUCL MED BIOL, V16, P675

[4] INVIVO METABOLISM AND KINETICS OF TC-99M-HMPAO [J].