APPROACHES TO CATALYTIC ASYMMETRIC FORMATION AND REACTIONS LITHIUM ENOLATES

被引：47

作者：

KOGA, K

SHINDO, M

机构：

[1] Faculty of Pharmaceutical Sciences, University of Tokyo

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 1995年 / 53卷 / 11期

关键词：

D O I：

10.5059/yukigoseikyokaishi.53.1021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Studies have been made to explore the use of chiral chelated lithium amides or their corresponding amines for enantioselective reactions. Some of our results are discussed in terms of enantioselective deprotonation of prochiral cyclic ketones, kinetic resolution of racemic 2-substituted cyclohexanones, regioselective deprotonation of optically active 3-keto steroids, enantioselective alkylation and protonation of achiral lithium enolates. Examples of catalytic asymmetric deprotonation and alkylation by the present strategy are also discussed.

引用

页码：1021 / 1032

页数：12

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