THE PREPARATION AND REACTIONS OF CHIRAL PHOSPHOROUS-ACID DIAMIDES

被引：36

作者：

KOELLER, KJ ^{[1
]}

SPILLING, CD ^{[1
]}

机构：

[1] UNIV MISSOURI,DEPT CHEM,8001 NAT BRIDGE RD,ST LOUIS,MO 63121

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 44期

关键词：

PHOSPHORUS ACID; CHIRAL; PHOSPHONAMIDE; ALKYLATION; DIAMINE;

D O I：

10.1016/0040-4039(91)80151-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral phosphorous acid diamides were prepared by condensation of N,N'-disubstituted C2 diamines with PCl3 followed by an equivalent of water. Deprotonation of these acids with n-butyl lithium or LDA gave the lithium salt which reacted smoothly with alkyl halides to give the substituted phosphonamides in good yield.

引用

页码：6297 / 6300

页数：4

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