CHANGES IN NEUROTROPHIN RESPONSIVENESS DURING THE DEVELOPMENT OF CEREBELLAR GRANULE NEURONS

被引：227

作者：

SEGAL, RA ^{[1
]}

TAKAHASHI, H ^{[1
]}

MCKAY, RDG ^{[1
]}

机构：

[1] MIT,DEPT BRAIN & COGNIT SCI,CAMBRIDGE,MA 02139

来源：

NEURON | 1992年 / 9卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0896-6273(92)90064-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotrophins and their receptors are widespread in the developing and mature CNS. Identifying the differentiation state of neurotrophin-responsive cells provides a basis for understanding the developmental functions of these factors. Studies using dissociated and organotypic cultures of rat cerebellum demonstrated that the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) affect developing granule cells at distinct stages in differentiation. While early granule neurons in the external germinal layer responded to BDNF, more mature granule cells responded to NT-3. BDNF, but not NT-3, enhanced survival of granule cells in cultures of embryonic cerebella. Thus, BDNF and NT-3 have distinct sequential functions that are likely to be critical in the development of the cerebellum. BDNF may promote the initial commitment, while NT-3 may direct the subsequent maturation of granule cells.

引用

页码：1041 / 1052

页数：12

共 51 条

[11] THE TRK TYROSINE PROTEIN-KINASE MEDIATES THE MITOGENIC PROPERTIES OF NERVE GROWTH-FACTOR AND NEUROTROPHIN-3 [J].