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INVITRO ACTIVITY OF RAMOPLANIN AGAINST VANCOMYCIN-RESISTANT GRAM-POSITIVE ORGANISMS

被引：37
作者：
COLLINS, LA
ELIOPOULOS, GM
WENNERSTEN, CB
FERRARO, MJ
MOELLERING, RC
机构：
[1] NEW ENGLAND DEACONESS HOSP,DEPT MED,BOSTON,MA 02215
[2] MASSACHUSETTS GEN HOSP,BOSTON,MA 02114
[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 06期
关键词：
D O I：
10.1128/AAC.37.6.1364
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In vitro activity of ramoplanin, a cyclic lipoglycopeptide, against 92 vancomycin-resistant gram-positive organisms was evaluated. Ramoplanin demonstrated potent activity against many highly vancomycin-resistant organisms including enterococci (MICs for 90% of strains tested of 0.5 mug/ml) and against Lactobacillus spp., Leuconostoc spp., and Pediococcus spp., all of which were inhibited at concentrations of less-than-or-equal-to 0.25 mug/ml. This drug or a derivative compound merits further investigation as a potential therapeutic agent for infections due to vancomycin-resistant enterococci.
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收藏
页码：1364 / 1366
页数：3
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