L-AP3 DOES NOT ANTAGONIZE HIPPOCAMPAL SYNAPTIC DEPRESSION INDUCED BY 1S,3R-ACPD

被引：5

作者：

GOH, JW

MUSGRAVE, MA

机构：

[1] Department of Pharmacology and Toxicology, Queen's University, Kingston

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 03期

基金：

英国医学研究理事会;

关键词：

METABOTROPIC RECEPTOR; SYNAPTIC TRANSMISSION; HIPPOCAMPUS;

D O I：

10.1016/0028-3908(93)90118-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1-Aminocyclopentane-trans-1S,3R-dicarboxylic acid (1S,3R-ACPD), a compound which selectively activates a metabotropic glutamate receptor (mGluR), suppresses hippocampal excitatory synaptic transmission. This depression is not antagonizable by L-2-amino-3-phosphonoproprionic acid (L-AP3), an agent which counteracts mGluR-induced phosphoinositide (PI) metabolism in several neuronal systems. Therefore, we believe that 1S,3R-ACPD activates a novel hippocampal mGluR subtype that is either insensitive to L-AP3 blockade and/or linked to an effector system that does not involve PI turnover.

引用

页码：311 / 312

页数：2

共 9 条

[1] TRANS-ACPD DEPRESSES SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].