DIFFERENT CHROMOSOMAL LOCALIZATION OF THE CLCN4 GENE IN MUS-SPRETUS AND C57BL/6J MICE

被引：74

作者：

RUGARLI, EI

ADLER, DA

BORSANI, G

TSUCHIYA, K

FRANCO, B

HAUGE, X

DISTECHE, C

CHAPMAN, V

BALLABIO, A

机构：

[1] TELETHON INST GENET & MED,MILAN,ITALY

[2] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195

[3] BAYLOR COLL MED,DEPT MOLEC & HUMAN GENET,HOUSTON,TX 77030

[4] ROSWELL PK CANC INST,DEPT MOLEC & CELL BIOL,BUFFALO,NY 14263

[5] UNIV SIENA,DEPT MOLEC BIOL,SIENA,ITALY

来源：

NATURE GENETICS | 1995年 / 10卷 / 04期

关键词：

D O I：

10.1038/ng0895-466

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region, Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.

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页码：466 / 471

页数：6

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