IRREVERSIBLE ENZYME-INHIBITORS .202. CANDIDATE ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF 5-FLUORO-2'-DEOXYURIDINE PHOSPHORYLASE FROM WALKER-256 RAT-TUMOR DERIVED FROM 1-BENZYL-5-(3-ETHOXYBENZYL)URACIL

被引：15

作者：

KELLEY, JL ^{[1
]}

BAKER, BR ^{[1
]}

机构：

[1] UNIV CALIF SANTA BARBARA,DEPT CHEM,SANTA BARBARA,CA 93106

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1982年 / 25卷 / 05期

关键词：

D O I：

10.1021/jm00347a022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：600 / 603

页数：4

共 30 条

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[5]

BAKER BR, 1970, J MED CHEM, V13, P458, DOI 10.1021/jm00297a028

[6] IRREVERSIBLE ENZYME INHIBITORS . 135 . EFFECT OF RING SUBSTITUTION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-(P-(P-FLUOROSULFONYLPHENYLUREIDO)PHENOXYMETHYL)PYRIMIDINE [J].

BAKER, BR ;

VERMEULEN, NM .

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[7] IRREVERSIBLE ENZYME INHIBITORS .188. INHIBITION OF MAMMALIAN THYMIDINE PHOSPHORYLASE [J].

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[8] ANALOGS OF TETRAHYDROFOLIC ACID .39(1,2). SELECTIVE BROMOACYLATION OF POLYFUNCTIONAL MOLECULES FOR SYNTHESIS OF ACTIVE-SITE-DIRECTED IRREVERSIBLE ENZYME INHIBITORS [J].

BAKER, BR ;

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[9] IRREVERSIBLE ENZYME INHIBITORS .169. INHIBITION OF FUDR PHOSPHORYLASE FROM WALKER-256 RAT TUMOR BY 6-SUBSTITUTED URACILS [J].

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[10]

Baker BR, 1967, DESIGN ACTIVE SITE D

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