HIGH-RESOLUTION EPITOPE MAPPING OF HGH-RECEPTOR INTERACTIONS BY ALANINE-SCANNING MUTAGENESIS

被引:1189
作者
CUNNINGHAM, BC [1 ]
WELLS, JA [1 ]
机构
[1] GENENTECH,DEPT BIOMOLEC CHEM,460 POINT SAN BRUNO BLVD,S SAN FRANCISCO,CA 94080
关键词
D O I
10.1126/science.2471267
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1081 / 1085
页数:5
相关论文
共 38 条
[11]   THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS) [J].
CARTER, PJ ;
WINTER, G ;
WILKINSON, AJ ;
FERSHT, AR .
CELL, 1984, 38 (03) :835-840
[12]   HIGH-LEVEL SECRETION OF HUMAN GROWTH-HORMONE BY ESCHERICHIA-COLI [J].
CHANG, CN ;
REY, M ;
BOCHNER, B ;
HEYNEKER, H ;
GRAY, G .
GENE, 1987, 55 (2-3) :189-196
[13]   NATURE OF ACCESSIBLE AND BURIED SURFACES IN PROTEINS [J].
CHOTHIA, C .
JOURNAL OF MOLECULAR BIOLOGY, 1976, 105 (01) :1-14
[14]   3-DIMENSIONAL STRUCTURE OF A COMPLEX OF ANTIBODY WITH INFLUENZA-VIRUS NEURAMINIDASE [J].
COLMAN, PM ;
LAVER, WG ;
VARGHESE, JN ;
BAKER, AT ;
TULLOCH, PA ;
AIR, GM ;
WEBSTER, RG .
NATURE, 1987, 326 (6111) :358-363
[15]  
CUNNINGHAM BA, UNPUB
[16]   RECEPTOR AND ANTIBODY EPITOPES IN HUMAN GROWTH-HORMONE IDENTIFIED BY HOMOLOG-SCANNING MUTAGENESIS [J].
CUNNINGHAM, BC ;
JHURANI, P ;
NG, P ;
WELLS, JA .
SCIENCE, 1989, 243 (4896) :1330-1336
[17]  
FUH G, UNPUB
[18]   FUNCTIONAL-ROLE OF ASPARTIC ACID-27 IN DIHYDROFOLATE-REDUCTASE REVEALED BY MUTAGENESIS [J].
HOWELL, EE ;
VILLAFRANCA, JE ;
WARREN, MS ;
OATLEY, SJ ;
KRAUT, J .
SCIENCE, 1986, 231 (4742) :1123-1128
[19]   SURFACE, SUBUNIT INTERFACES AND INTERIOR OF OLIGOMERIC PROTEINS [J].
JANIN, J ;
MILLER, S ;
CHOTHIA, C .
JOURNAL OF MOLECULAR BIOLOGY, 1988, 204 (01) :155-164
[20]  
KATZ BA, 1986, J BIOL CHEM, V261, P5480