IDENTIFICATION OF NOVEL FLUORESCENT PYRROLOPYRIDINIUM COMPOUND FORMED FROM MAILLARD REACTION OF 3-DEOXYGLUCOSONE AND BUTYLAMINE

被引：25

作者：

HAYASE, F ^{[1
]}

HINUMA, H ^{[1
]}

ASANO, M ^{[1
]}

KATO, H ^{[1
]}

ARAI, S ^{[1
]}

机构：

[1] UNIV TOKYO, DEPT AGR CHEM, TOKYO 113, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 10期

关键词：

D O I：

10.1271/bbb.58.1936

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A major fluorescent compound (FL-C) was generated in a butylamine-glucose or 3-deoxyglucosone (3DG) reaction system under physiological conditions of 37 degrees C at pH 7.4. FL-C was purified from the butylamine-3DG reaction system and identified as 6,8-dibutyl-3,3a,8,8a-tetrahydro-3a-hydroxy-2-(1,2-dihydroxyethyl)-5-hydroxymethyl-2H-furo[3',2':4,5]pyrrolo-[2,3-c]pyridinium. The compound was formed by the loss of five molecules of water from the reaction between 2 molecules of butylamine and 2 molecules of 3DG.

引用

页码：1936 / 1937

页数：2

共 8 条

[1] METABOLISM OF 3-DEOXYGLUCOSONE, AN INTERMEDIATE COMPOUND IN THE MAILLARD REACTION, ADMINISTERED ORALLY OR INTRAVENOUSLY TO RATS
KATO, H
VANCHUYEN, N
SHINODA, T
SEKIYA, F
HAYASE, F
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1035 (01) : 71 - 76
[2] Kato H, 1989, Prog Clin Biol Res, V304, P69
[3] 3-DEOXYGLUCOSONE CROSS-LINKS PROTEINS UNDER PHYSIOLOGICAL CONDITIONS
KATO, H
SHIN, DB
HAYASE, F
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1987, 51 (07): : 2009 - 2011
[4] RESPONSIBILITY OF 3-DEOXYGLUCOSONE FOR THE GLUCOSE-INDUCED POLYMERIZATION OF PROTEINS
KATO, H
CHO, RK
OKITANI, A
HAYASE, F
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1987, 51 (03): : 683 - 689
[5] NEW ASPECTS OF THE MAILLARD REACTION IN FOODS AND IN THE HUMAN-BODY
LEDL, F
SCHLEICHER, E
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1990, 29 (06) : 565 - 594
[6] CROSSLINES A AND B AS CANDIDATES FOR THE FLUOROPHORES IN AGE-RELATED AND DIABETES-RELATED CROSS-LINKED PROTEINS, AND THEIR DIACETATES PRODUCED BY MAILLARD REACTION OF ALPHA-N-ACETYL-L-LYSINE WITH D-GLUCOSE
NAKAMURA, K
HASEGAWA, T
FUKUNAGA, Y
IENAGA, K
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (14) : 992 - 994
[7] SELL DR, 1989, J BIOL CHEM, V264, P21597
[8] PROTEIN GLYCATION AND OXIDATIVE STRESS IN DIABETES-MELLITUS AND AGING
WOLFF, SP
JIANG, ZY
HUNT, JV
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (05) : 339 - 352

← 1 →