EFFECTS OF K+ CHANNEL OPENERS ON THE VASCULAR ACTIONS OF HUMAN GAMMA-GLOBULIN

被引：2

作者：

ABRAHAMS, Z ^{[1
]}

SUTTER, MC ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,VANCOUVER V6T 1Z3,BC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 02期

关键词：

K+ ACTIVATOR/OPENER; K+ CHANNEL INACTIVATOR/CLOSER; GAMMA GLOBULIN; HUMAN; MESENTERIC PORTAL VEIN;

D O I：

10.1016/0014-2999(94)90597-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to determine if the stimulatory action of human gamma globulin on the spontaneous activity of the rat mesenteric portal vein is due to decreased K+ conductance. Glibenclamide potentiated the action of human gamma-globulin on the portal vein by 45% and on its own had a concentration- and time-dependent biphasic (increase followed by a decrease) effect on the spontaneous activity of the portal vein. Diazoxide and pinacidil both inhibited the action of human gamma-globulin on the rat mesenteric portal vein. Levcromakalim (BRL 38227) potentiated the stimulatory action of human gamma-globulin on the integrated force of the spontaneous contractions of the rat mesenteric portal vein by 40% and 49% at concentrations of 0.5 and 5 mu M, respectively. These studies suggest that human gamma-globulin can act by directly modulating a K+ channel.

引用

页码：195 / 203

页数：9

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