CARBOXYPEPTIDASE-MEDIATED RELEASE OF METHOTREXATE FROM METHOTREXATE ALPHA-PEPTIDES

被引:51
作者
KUEFNER, U [1 ]
LOHRMANN, U [1 ]
MONTEJANO, YD [1 ]
VITOLS, KS [1 ]
HUENNEKENS, FM [1 ]
机构
[1] SCRIPPS CLIN & RES FDN, RES INST, DEPT BASIC & CLIN RES, DIV BIOCHEM, LA JOLLA, CA 92037 USA
关键词
D O I
10.1021/bi00431a047
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:2288 / 2297
页数:10
相关论文
共 27 条
[11]  
LEVY CC, 1967, J BIOL CHEM, V242, P2933
[12]  
MCCULLOUGH JL, 1971, J BIOL CHEM, V246, P7207
[14]   SYNTHESES OF ALPHA-SUBSTITUTED AND GAMMA-SUBSTITUTED AMIDES, PEPTIDES, AND ESTERS OF METHOTREXATE AND THEIR EVALUATION AS INHIBITORS OF FOLATE METABOLISM [J].
PIPER, JR ;
MONTGOMERY, JA ;
SIROTNAK, FM ;
CHELLO, PL .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (02) :182-187
[15]   A POTENT MERCAPTO BI-PRODUCT ANALOG INHIBITOR FOR HUMAN CARBOXYPEPTIDASE-N [J].
PLUMMER, TH ;
RYAN, TJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 98 (02) :448-454
[16]   PHOTOAFFINITY ANALOGS OF METHOTREXATE AS FOLATE ANTAGONIST BINDING PROBES .2. TRANSPORT STUDIES, PHOTOAFFINITY-LABELING, AND IDENTIFICATION OF THE MEMBRANE CARRIER PROTEIN FOR METHOTREXATE FROM MURINE L1210 CELLS [J].
PRICE, EM ;
FREISHEIM, JH .
BIOCHEMISTRY, 1987, 26 (15) :4757-4763
[17]  
REICH E, 1975, PROTEASES BIOL CONTR, P357
[18]   METHOTREXATE ANALOGS .14. SYNTHESIS OF NEW GAMMA-SUBSTITUTED DERIVATIVES AS DIHYDROFOLATE-REDUCTASE INHIBITORS AND POTENTIAL ANTICANCER AGENTS [J].
ROSOWSKY, A ;
FORSCH, R ;
UREN, J ;
WICK, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (12) :1450-1455
[19]   METHOTREXATE ANALOGS .10. DIRECT COUPLING OF METHOTREXATE AND DIETHYL L-GLUTAMATE IN PRESENCE OF PEPTIDE BOND-FORMING REAGENTS [J].
ROSOWSKY, A ;
YU, CS .
JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (02) :170-175
[20]   METHOTREXATE ANALOGS .25. CHEMICAL AND BIOLOGICAL STUDIES ON THE GAMMA-TERT-BUTYL ESTERS OF METHOTREXATE AND AMINOPTERIN [J].
ROSOWSKY, A ;
FREISHEIM, JH ;
BADER, H ;
FORSCH, RA ;
SUSTEN, SS ;
CUCCHI, CA ;
FREI, E .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (05) :660-667