MITOCHONDRIAL DISEASES - GENOTYPE VERSUS PHENOTYPE

被引：100

作者：

WALLACE, DC

机构：

[1] Department of Genetics and Molecular Medicine, Emory University Medical School, Atlanta, GA 30322

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 04期

关键词：

D O I：

10.1016/0168-9525(93)90207-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recently, a variety of degenerative diseases have been attributed to mutations in mitochondrial DNA. Even though these mutations are inherited and present throughout the body, they frequently cause late-onset, tissue-specific disease. This may be explained by a combination of the tissue-specific accumulation of somatic mtDNA mutations with age and the variation between tissues in the expression of nuclear genes that encode mitochondrial functions.

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页码：128 / 133

页数：6

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