TRANSACTIVATION BY AP-1 IS A MOLECULAR TARGET OF T-CELL CLONAL ANERGY

被引：335

作者：

KANG, SM

BEVERLY, B

TRAN, AC

BRORSON, K

SCHWARTZ, RH

LENARDO, MJ

机构：

[1] NIAID,IMMUNOL LAB,BETHESDA,MD 20892

[2] NIAID,CELLULAR & MOLEC IMMUNOL LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1992年 / 257卷 / 5073期

关键词：

D O I：

10.1126/science.257.5073.1134

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.

引用

页码：1134 / 1138

页数：5

共 79 条

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