DETERMINATION OF THE GROWTH PROMOTER, 4-HYDROXY-3-NITROPHENYL-ARSONIC ACID IN CHICKEN TISSUE BY COUPLED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY

被引:36
作者
DEAN, JR
EBDON, L
FOULKES, ME
CREWS, HM
MASSEY, RC
机构
[1] UNIV PLYMOUTH,PLYMOUTH ANALYT CHEM RES UNIT,DRAKE CIRCUS,PLYMOUTH PL4 8AA,DEVON,ENGLAND
[2] MAFF,FOOD SAFETY DIRECTORATE,DIV FOOD SCI,NORWICH NR4 7UQ,ENGLAND
关键词
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; ARSENIC SPECIATION; 4-HYDROXY-3-NITROPHENYLARSONIC ACID; CHICKEN TISSUE; FOOD ANALYSIS;
D O I
10.1039/ja9940900615
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A method has been developed to measure the levels of the growth promoter 4-hydroxy-3-nitrophenylarsonic acid (roxarsone) in samples of tissue from chickens fed on a diet supplemented with this compound. Extracts of the tissue were prepared for analysis by a trypsin enzymolysis digestion technique and bulk matrix separation was performed by anion-exchange column chromatography. Further separation of the roxarsone from other species was achieved using reversed-phase high-performance liquid chromatography. Detection of the arsenical compound was by inductively coupled plasma mass spectrometry. No roxarsone was detected in chickens fed on the supplemented diet with or without a withdrawal period (7 d on base feed after the administration period) at a quantification limit of 25 ng g-1. Recoveries for roxarsone from spiked (standard additions) samples of chicken tissue varied between 85 and 103%.
引用
收藏
页码:615 / 618
页数:4
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