TRANSFORMING GROWTH-FACTOR-BETA - A MATTER OF LIFE AND DEATH

被引：285

作者：

MCCARTNEYFRANCIS, NL ^{[1
]}

WAHL, SM ^{[1
]}

机构：

[1] NIDR, IMMUNOL LAB, CELLULAR IMMUNOL SECT, BETHESDA, MD 20892 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1994年 / 55卷 / 03期

关键词：

TRANSFORMING GROWTH FACTOR BETA; INFLAMMATION; TRANSGENICS; GENE TARGETING; THERAPY; FIBROSIS; CYTOKINES; LEUKOCYTES; EMBRYOGENESIS;

D O I：

10.1002/jlb.55.3.401

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A wide variety of functions, many of which represent opposing activities, have been attributed to TGF-beta, a molecule implicated in embryogenesis, development, and immune and inflammatory processes. This paradoxical behavior of promoting or inhibiting cell growth and function, while important in normal physiology and homeostasis, can contribute to or interrupt pathologic sequelae, making TGF-beta a particularly intriguing molecule for study. New transgenic mouse models displaying targeted alterations in TGF-beta 1 expression offer novel and unique opportunities to determine the essential function(s) of TGF-beta.

引用

页码：401 / 409

页数：9

共 112 条

[51]

LEHNERT SA, 1988, DEVELOPMENT, V104, P263

[52]

LEVINE JH, 1993, AM J PATHOL, V143, P368

[53] EXPRESSION CLONING OF THE TGF-BETA TYPE-II RECEPTOR, A FUNCTIONAL TRANSMEMBRANE SERINE THREONINE KINASE [J].

LIN, HY ;

WANG, XF ;

NGEATON, E ;

WEINBERG, RA ;

LODISH, HF .

CELL, 1992, 68 (04) :775-785

[54] TRANSFORMING GROWTH FACTOR-BETA(1) AND BASIC FIBROBLAST GROWTH-FACTOR IN THE INJURED CNS [J].

LOGAN, A ;

BERRY, M .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (09) :337-343

[55] STRUCTURE AND EXPRESSION OF THE MEMBRANE PROTEOGLYCAN BETAGLYCAN, A COMPONENT OF THE TGF-BETA RECEPTOR SYSTEM [J].

LOPEZCASILLAS, F ;

CHEIFETZ, S ;

DOODY, J ;

ANDRES, JL ;

LANE, WS ;

MASSAGUE, J .

CELL, 1991, 67 (04) :785-795

[56] BETAGLYCAN PRESENTS LIGAND TO THE TGF-BETA SIGNALING RECEPTOR [J].

LOPEZCASILLAS, F ;

WRANA, JL ;

MASSAGUE, J .

CELL, 1993, 73 (07) :1435-1444

[57] TRANSFORMING GROWTH FACTOR-BETA-2 - CDNA CLONING AND SEQUENCE-ANALYSIS [J].

MADISEN, L ;

WEBB, NR ;

ROSE, TM ;

MARQUARDT, H ;

IKEDA, T ;

TWARDZIK, D ;

SEYEDIN, S ;

PURCHIO, AF .

DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1988, 7 (01) :1-8

[58] SEQUENCE-ANALYSIS OF THE PROMOTER REGION OF THE GLIOBLASTOMA DERIVED T-CELL SUPPRESSOR FACTOR TRANSFORMING GROWTH-FACTOR (TGF)-BETA-2 GENE REVEALS STRIKING DIFFERENCES TO THE TGF-BETA-1 AND TGF-BETA-3 GENES [J].

MALIPIERO, U ;

HOLLER, M ;

WERNER, U ;

FONTANA, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (03) :1145-1151

[59]

MASSAGUE J, 1992, CANCER SURV, V12, P81

[60] TGF-beta Regulates Production of Growth Factors and TGF-beta by Human Peripheral Blood Monocytes [J].

McCartney-Francis, Nancy ;

Mizel, Diane ;

Wong, Henry ;

Wahl, Larry ;

Wahl, Sharon .

GROWTH FACTORS, 1990, 4 (01) :27-35

← 1 2 3 4 5 6 7 8 9 10 →