CROSS-RESISTANCE TO POLYENE AND AZOLE DRUGS IN CRYPTOCOCCUS-NEOFORMANS

被引：49

作者：

JOSEPHHORNE, T

HOLLOMON, D

LOEFFLER, RST

KELLY, SL

机构：

[1] UNIV SHEFFIELD,KREBS INST BIOMOLEC RES,DEPT MOLEC BIOL & BIOTECHNOL,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

[2] UNIV BRISTOL,INST ARABLE CROPS RES,LONG ASHTON RES STN,DEPT AGR SCI,BRISTOL,AVON,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.39.7.1526

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fluconazole was observed to inhibit sterol 14 alpha-demethylase in the human pathogen Cryptococcus neoformans, and accumulation of a ketosteroid product was associated with growth arrest. A novel mechanism(s) of azole and amphotericin B cross-resistance was identified, unrelated to changes in sterol biosynthesis, as previously identified in Saccharomyces cerevisiae, Reduced cellular content of drug could account for the resistance phenotype, indicating the possible involvement of a mechanism similar to multidrug resistance observed in higher eukaryotes.

引用

页码：1526 / 1529

页数：4

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