Imaging of brain iron by magnetic resonance: T-2 relaxation at different field strengths

Soon after the advent of magnetic resonance imaging (MRI) as a diagnostic modality in the 1980s, it was recognized that some of the contrast found in brain imaging correlated with patterns of iron deposition. The presence of non-heme iron had previously been established by pathological studies on post-mortem brains. The iron concentration is highest in specific nuclei of the basal ganglia and some associated structures. It is low at birth and increases with age until a relatively constant level is reached at an age of 20-30 years. There is evidence for further increases in very elderly persons. Although iron is ubiquitous in human tissues, only in a few situations is the concentration large enough to affect MRI. Because MRI has the ability to detect, in a noninvasive fashion, the naturally occurring iron in the basal ganglia and related nuclei, it may be used to study the physiology and pathology of these important structures. Magnetic resonance imaging has confirmed the results of earlier post mortem studies of the anatomical localization and age-dependence of brain iron. Initial steps have been taken toward the use of MRI to study disorders of thought, movement, and behavior that are believed to be related to brain iron. However, additional understanding is required of the physical details of the contrast mechanism, the physiology of the iron accumulation, and the significance of abnormal patterns of Iron deposition. In this report, data are presented on the normal variation in MRI parameters and their dependence on magnetic field strength. The potential clinical and basic science applications are briefly reviewed. Information from widely differing fields is relevant to the study of the physical and pathological significance of brain iron, and for this reason, extensive, although not exhaustive, literature references are included.