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CYCLOSPORINE-A INDUCES ENDOTHELIN-1 RELEASE FROM CULTURED RAT VASCULAR SMOOTH-MUSCLE CELLS

被引：32
作者：
TAKEDA, Y
ITOH, Y
YONEDA, T
MIYAMORI, I
TAKEDA, R
机构：
[1] Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 233卷 / 2-3期
关键词：
CYCLOSPORINE-A; ENDOTHELIN; SMOOTH MUSCLE CELL (VASCULAR); (RAT);
D O I：
10.1016/0014-2999(93)90066-Q
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since vascular smooth muscle cells in culture are capable of secreting endothelin-I (ET-1), we investigated the effect of cyclosporine A on ET-1 release from rat vascular smooth muscle cells. Cyclosporine A 10 muM significantly (P < 0.05) enhanced the secretion of ET-1 at 2, 8, 24 and 48 h (6.5 +/- 0.5, 11 +/- 0.7, 19 +/- 0.5, 37 +/- 1.6 fmol/10(6) cells, respectively) compared with vehicle (4.7 +/- 0.3, 8.1 +/- 0.6, 15 +/- 0.4, 27 +/- 2.0 fmol/10(6) cells, respectively). The cyclosporine-induced synthesis of ET-1 by vascular smooth muscle cell may participate in the pathogenesis of cyclosporine-induced vasoconstriction and vasculopathy via an autocrine regulatory mechanism.
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页码：299 / 301
页数：3
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