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CHARACTERIZATION OF A PROMOTER REGION SUPPORTING TRANSCRIPTION OF A NOVEL HUMAN BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE TRANSCRIPT IN HEPG2 CELLS

被引：34
作者：
AASENG, DA
ASHEIM, HC
DEGGERDAL, A
SMELAND, E
FUNDERUD, S
机构：
[1] Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1261卷 / 01期
关键词：
BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE; TRANSCRIPTIONAL REGULATION; ACUTE PHASE REACTANT; INTERLEUKIN; 6; INDUCTION; (HEPG2 CELL);
D O I：
10.1016/0167-4781(94)00250-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In humans, two transcripts encoding beta-galactoside alpha-2,6-sialyltransferase (EC 2.4.99.1) have previously been described. One of the transcripts is widely expressed, whereas the other is restricted to mature B-cells. In this study we demonstrate the existence of a third transcript in the hepatoma cell-line HepG2. The expression of this transcripted is controlled by a promoter region which efficiently supports transcription in HepG2 cells, and which harbours putative binding sites for liver-enriched and acute phase inducible transcription factors.
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页码：166 / 169
页数：4
相关论文
共 37 条
[1]   CELL-SPECIFIC EXPRESSION OF HUMAN BETA-GALACTOSIDE ALPHA-2,6-SIALYTRANSFERASE TRANSCRIPTS DIFFERING IN THE 5' UNTRANSLATED REGION [J].
AASHEIM, HC ;
AASENG, DA ;
DEGGERDAL, A ;
BLOMHOFF, HK ;
FUNDERUD, S ;
SMELAND, EB .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 213 (01) :467-475
[2]  
DALLOLIO F, 1989, INT J CANCER, V44, P434
[3]   CELL CYCLE-DEPENDENT REGULATION OF CDW75 (BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE) ON HUMAN LYMPHOCYTES-B [J].
ERIKSTEIN, BK ;
FUNDERUD, S ;
BEISKE, K ;
AASENG, A ;
DAVIES, CD ;
BLOMHOFF, HK ;
SMELAND, EB .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (05) :1149-1155
[4]   INTERFERON BETA-2/B-CELL STIMULATORY FACTOR TYPE-2 SHARES IDENTITY WITH MONOCYTE-DERIVED HEPATOCYTE-STIMULATING FACTOR AND REGULATES THE MAJOR ACUTE PHASE PROTEIN RESPONSE IN LIVER-CELLS [J].
GAULDIE, J ;
RICHARDS, C ;
HARNISH, D ;
LANSDORP, P ;
BAUMANN, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7251-7255
[5]  
GRANGE T, 1990, NUCLEIC ACIDS RES, V19, P131
[6]  
GRUNDMANN U, 1990, NUCLEIC ACIDS RES, V18, P167
[7]   2 DISTINCT FACTORS INTERACT WITH THE PROMOTER REGIONS OF SEVERAL LIVER-SPECIFIC GENES [J].
HARDON, EM ;
FRAIN, M ;
PAONESSA, G ;
CORTESE, R .
EMBO JOURNAL, 1988, 7 (06) :1711-1719
[8]  
HOCKE GM, 1992, MOL CELL BIOL, V12, P282
[9]   REGULATION OF EXPRESSION OF BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE IN A RAT-TUMOR, ZAJDELA ASCITIC HEPATOMA [J].
JAIN, N ;
SUDHAKAR, C ;
DAS, MR .
FEBS LETTERS, 1993, 317 (1-2) :147-151
[10]   SIALYLTRANSFERASE - A NOVEL ACUTE-PHASE REACTANT [J].
JAMIESON, JC ;
MCCAFFREY, G ;
HARDER, PG .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1993, 105 (01) :29-33
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