LIPASE-MEDIATED HYDROLYSIS OF RAPAMYCIN 42-HEMISUCCINATE BENZYL AND METHYL-ESTERS

被引：12

作者：

ADAMCZYK, M

GEBLER, JC

MATTINGLY, PG

机构：

[1] Divisional Organic Chemistry Research (D-9NM), Abbott Diagnostics Division, Abbott Laboratories, Abbott Park

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)79954-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzyl and methyl esters of rapamycin 42-hemisuccinate were hydrolyzed under very mild conditions to the rapamycin hemisuccinate using lipase from Pseudomonas sp. This selective deprotection was performed on a greater than or equal to 100 mg scale for both eaters resulting in 50% isolated yield from the methyl ester and 29% from the benzyl ester of the desired acid.

引用

页码：1019 / 1022

页数：4

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