SYNTHESIS OF 2-DEOXY-2-FLUORINATED INOSITOL-1-O-DODECYLPHOSPHONATES AS INHIBITORS OF GLYCOSYL PHOSPHATIDYLINOSITOL PHOSPHOLIPASE-C

被引：14

作者：

ZHAI, HX

LEI, PS

MORRIS, JC

MENSAWILMOT, K

SHEN, TY

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

[2] UNIV GEORGIA,DEPT CELLULAR BIOL,ATHENS,GA 30602

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

关键词：

D O I：

10.1016/0040-4039(95)01579-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three 2-deoxy-2-fluorinated inositols and their 1-O-dodecylphosphonate derivatives have been synthesized as non-cleavable inhibitors of glycosyl phosphatidylinositol phospholipase C. Their structure-activity relationship is discussed.

引用

页码：7403 / 7406

页数：4

共 8 条

[1] DERIVATIVES OF 2,3,4,5,6-PENTA-O-BENZYL-MYO-INOSITOL [J].

GIGG, R ;

WARREN, CD .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (18) :2367-&

[2] SYNTHESIS OF DEOXY AND DEOXYHALOGENO ANALOGS OF MYOINOSITOL [J].

JIANG, C ;

MOYER, JD ;

BAKER, DC .

JOURNAL OF CARBOHYDRATE CHEMISTRY, 1987, 6 (03) :319-355

[3]

JIANG C, 1990, CARBOHYD RES, P207

[4]

JIANG C, 1990, CARBOHYD RES, P277

[5] ACTIVATION OF THE ALPHA-INTERNEXIN PROMOTER BY THE BRN-3A TRANSCRIPTION FACTOR IS DEPENDENT ON THE N-TERMINAL REGION OF THE PROTEIN [J].

BUDHRAMMAHADEO, V ;

MORRIS, PJ ;

LAKIN, ND ;

THEIL, T ;

CHING, GY ;

LILLYCROP, KA ;

MOROY, T ;

LIEM, RKH ;

LATCHMAN, DS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2853-2858

[6] TOTAL SYNTHESIS OF FLUORINATED ANALOGS OF INOSITOL AND INOSITOL 1,4,5-TRISPHOSPHATE [J].

SAWYER, DA ;

POTTER, BVL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (07) :923-932

[7] STEREOSELECTIVE REDUCTION OF ALPHA,BETA-EPOXY KETONES WITH SODIUM-BOROHYDRIDE IN THE PRESENCE OF CALCIUM-CHLORIDE OR LANTHANUM CHLORIDE - A PRACTICAL PREPARATION OF ERYTHRO-ALPHA,BETA-EPOXY ALCOHOLS [J].

TANIGUCHI, M ;

FUJII, H ;

OSHIMA, K ;

UTIMOTO, K .

TETRAHEDRON, 1995, 51 (03) :679-686

[8] SYNTHESIS OF FLUORODEOXYSCYLLOINOSITOL AND PHOSPHATIDYLFLUORODEOXYSCYLLOINOSITOL [J].

YANG, SS ;

BEATTIE, TR ;

SHEN, TY .

TETRAHEDRON LETTERS, 1982, 23 (52) :5517-5520

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