SYNTHESIS AND BIODISTRIBUTION OF IN-111, GA-67 AND GD-153-RADIOLABELED CONJUGATES OF NITROIMIDAZOLES WITH BIFUNCTIONAL COMPLEXING AGENTS - IMAGING AGENTS FOR HYPOXIC TISSUE

被引：14

作者：

NORMAN, TJ

SMITH, FC

PARKER, D

HARRISON, A

ROYLE, L

WALKER, CA

机构：

[1] UNIV DURHAM,DEPT CHEM,DURHAM DH1 3LE,ENGLAND

[2] MRC,RADIOBIOL UNIT,DIDCOT OX11 0RD,ENGLAND

来源：

SUPRAMOLECULAR CHEMISTRY | 1995年 / 4卷 / 04期

关键词：

D O I：

10.1080/10610279508028940

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugates of the putative hypoxia-selective agent 2-nitroimidazole with bifunctional complexing agents have been prepared and radiolabelled with In-111, Ga-67 or Gd-153. Although some evidence for tumour localisation was found control experiments revealed that the gallium and indium labelled complexes of the simple ligand 1,4,7-triazacyclononane-triacetate are themselves promising tumour-imaging agents.

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页码：305 / 308

页数：4

相关论文

共 23 条

[1] STRUCTURE AND SOLUTION STABILITY OF INDIUM AND GALLIUM COMPLEXES OF 1,4,7-TRIAZACYCLONONANETRIACETATE AND OF YTTRIUM COMPLEXES OF 1,4,7,10-TETRAAZACYCLODODECANETETRAACETATE AND RELATED LIGANDS - KINETICALLY STABLE COMPLEXES FOR USE IN IMAGING AND RADIOIMMUNOTHERAPY - X-RAY MOLECULAR-STRUCTURE OF THE INDIUM AND GALLIUM COMPLEXES OF 1,4,7-TRIAZACYCLONONANE-1,4,7-TRIACETIC ACID [J].

BROAN, CJ ;

COX, JPL ;

CRAIG, AS ;

KATAKY, R ;

PARKER, D ;

HARRISON, A ;

RANDALL, AM ;

FERGUSON, G .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1991, (01) :87-99

[2]

CHAPMAN JD, 1989, INT J RADIAT ONCOL, V16, P911

[3] NAD(P)H NITROBLUE TETRAZOLIUM REDUCTASE LEVELS IN APPARENTLY NORMOXIC TISSUES - A HISTOCHEMICAL-STUDY CORRELATING ENZYME-ACTIVITY WITH BINDING OF RADIOLABELED MISONIDAZOLE [J].

COBB, LM ;

HACKER, T ;

NOLAN, J .

BRITISH JOURNAL OF CANCER, 1990, 61 (04) :524-529

[4] TISSUE DISTRIBUTION OF C-14-LABELED AND H-3 LABELED MISONIDAZOLE IN THE TUMOR-BEARING MOUSE [J].

COBB, LM ;

NOLAN, J ;

BUTLER, S .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 18 (02) :347-351

[5] SYNTHESIS OF C-FUNCTIONALIZED AND N-FUNCTIONALIZED DERIVATIVES OF 1,4,7-TRIAZACYCLONONANE-1,4,7-TRIYLTRIACETIC ACID (NOTA), 1,4,7,10-TETRA-AZACYCLODODECANE-1,4,7,10-TETRAYLTETRA-ACETIC ACID (DOTA), AND DIETHYLENENETRIAMINEPENTA-ACETIC ACID (DTPA) - BIFUNCTIONAL COMPLEXING AGENTS FOR THE DERIVATIZATION OF ANTIBODIES [J].

COX, JPL ;

CRAIG, AS ;

HELPS, IM ;

JANKOWSKI, KJ ;

PARKER, D ;

EATON, MAW ;

MILLICAN, AT ;

MILLAR, K ;

BEELEY, NRA ;

BOYCE, BA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (09) :2567-2576

[6] TOWARDS TUMOR IMAGING WITH IN-111 LABELED MACROCYCLE ANTIBODY CONJUGATES [J].

CRAIG, AS ;

HELPS, IM ;

JANKOWSKI, KJ ;

PARKER, D ;

BEELEY, NRA ;

BOYCE, BA ;

EATON, MAW ;

MILLICAN, AT ;

MILLAR, K ;

PHIPPS, A ;

RHIND, SK ;

HARRISON, A ;

WALKER, C .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (12) :794-796

[7]

DIROCCO RJ, 1992, J NUCL MED, V33, P865

[8] HEPATOBILIARY AND RENAL EXCRETION IN MICE OF CHARGED AND NEUTRAL GADOLINIUM COMPLEXES OF CYCLIC TETRA-AZA-PHOSPHINIC AND CARBOXYLIC-ACIDS [J].

HARRISON, A ;

WALKER, CA ;

PEREIRA, KA ;

PARKER, D ;

ROYLE, L ;

PULUKKODY, K ;

NORMAN, TJ .

MAGNETIC RESONANCE IMAGING, 1993, 11 (06) :761-770

[9] GA-67 9N3 UPTAKE BY XENOGRAFTS OF HUMAN MELANOTIC MELANOMA IN MICE [J].

HARRISON, A ;

WALKER, CA ;

PEREIRA, KA ;

PARKER, D ;

ROYLE, L ;

MATTHEWS, RC ;

CRAIG, AS .

NUCLEAR MEDICINE COMMUNICATIONS, 1992, 13 (09) :667-672

[10]

HARRISON A, 1995, UNPUB NUCL MED COMMU